|
KMID : 0388120020110040369
|
|
Journal of Korean Society for the Study of Obesity
2002 Volume.11 No. 4 p.369 ~ p.376
|
|
|
Relationships between Serum Ghrelin Levels, Serum Leptin Levels and잸nthropometric Data in Koreans
|
|
Kim Eun-Hyuk
Kim Dae-Hyun
Suh Young-Sung
|
|
|
Abstract
|
|
|
Ghrelin is a peptide secreted mainly by gastric parietal cells that may play a role in appetite regulation. It appears to block leptin action. In cross sectional studies, fasting serum ghrelin level was inversely correlated, although this was robust relationship between ghrelin and BMI, and leptin level was positively correlated with BMI. The aims of the this study was to determined relationship between serum ghrelin level and leptin levels, anthropometric data in Koreans.
135 subjects (42 male, 93 female, BMI; 18.5 ~ 46.7 kg/㎡) were selected from obesity clinic and Health Promotion Center, Keimyung University Dongsan Medical Center in Daegu, Korea. Waist and hip circumference, BMI, abdominal visceral fat amount and subcutaneous fat amount by CT were measured. Serum ghrelin and leptin, respectively, were measured using a commercial RIA (Phoenix Pharmaceuticals, Belmont, CA, USA) (IRMA, DSL-23100, Diagnostic Systems Lab. Inc., Webster, TX, USA).
In female subjects, subjects with serum ghrelin level ≥ 600 ng/mL were significant different from subjects with serum ghrelin level <600ng/mL in BMI, waist and hip circumference, and abdominal fat amount by CT (P<0.05). Inverse correlations were observed between serum ghrelin and BMI, waist and hip circumference, WHR, visceral fat and subcutaneous fat in female subjects (P<0.01). In male subjects, serum ghrelin level did not correlated with anthropometric data. Serum ghrelin levels were negatively correlated with serum leptin levels in female subject (r=0.234, P<0.05). Entering significant variables into stepwise multiple regression model reveals that subcutaneous fat amount was independent predictors of leptin in male and female subjects (R^2 0.569, R^2 0.438).
These findings suggest that serum ghrelin levels were negatively correlated with serum leptin level and anthropometric data in Korean women.
|
|
|
KEYWORD
|
|
|
Ghrelin, Leptin, Obesity, Anthropometric data
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|